Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing

Insulin-like growth factors (IGFs) are important local regulators during fracture healing. Although IGF1 deficiency is known to increase the risk of delayed union or non-union fractures in the elderly population, the underlying mechanisms that contribute to this defect remains unclear. In this study...

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Pubblicato in:J Bone Miner Res
Autori principali: Wang, Tao, Wang, Yongmei, Menendez, Alicia, Fong, Chak, Babey, Muriel, Tahimic, Candice GT, Cheng, Zhiqiang, Li, Alfred, Chang, Wenhan, Bikle, Daniel D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5690481/
https://ncbi.nlm.nih.gov/pubmed/25801198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2510
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