Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading

Skeletal loading and unloading has a pronounced impact on bone remodeling, a process also regulated by insulin-like growth factor 1 (IGF-1) signaling. Skeletal unloading leads to resistance to the anabolic effect of IGF-1, while reloading after unloading restores responsiveness to IGF-1. However, a...

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Bibliographische Detailangaben
Hauptverfasser: Kubota, Takuo, Elalieh, Hashem Z., Saless, Neema, Fong, Chak, Wang, Yongmei, Babey, Muriel, Cheng, Zhiqiang, Bikle, Daniel D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747570/
https://ncbi.nlm.nih.gov/pubmed/23976802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actaastro.2012.08.007
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