Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas

The tumor-selective viral replication capacity and pro-apoptotic effects of oncolytic reovirus have been reported to be dependent on the presence of an activated RAS pathway in several solid tumor types. However, the mechanisms of selective anticancer efficacy of the reovirus-based formulation for c...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Carew, Jennifer S., Espitia, Claudia M., Zhao, Weiguo, Mita, Monica M., Mita, Alain C., Nawrocki, Steffan T.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689724/
https://ncbi.nlm.nih.gov/pubmed/29156834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21423
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