ELR510444 Inhibits Tumor Growth and Angiogenesis by Abrogating HIF Activity and Disrupting Microtubules in Renal Cell Carcinoma

BACKGROUND: Hypoxia-inducible factor (HIF) is an attractive therapeutic target for renal cell carcinoma (RCC) as its high expression due to the loss of von Hippel-Lindau (VHL) promotes RCC progression. Considering this, we hypothesized that ELR510444, a novel orally available small molecule inhibito...

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Bibliografische gegevens
Hoofdauteurs: Carew, Jennifer S., Esquivel, Juan A., Espitia, Claudia M., Schultes, Christoph M., Mülbaier, Marcel, Lewis, Joe D., Janssen, Bernd, Giles, Francis J., Nawrocki, Steffan T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266297/
https://ncbi.nlm.nih.gov/pubmed/22295124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031120
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