Lucanthone Is a Novel Inhibitor of Autophagy That Induces Cathepsin D-mediated Apoptosis

Cellular stress induced by nutrient deprivation, hypoxia, and exposure to many chemotherapeutic agents activates an evolutionarily conserved cell survival pathway termed autophagy. This pathway enables cancer cells to undergo self-digestion to generate ATP and other essential biosynthetic molecules...

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Главные авторы: Carew, Jennifer S., Espitia, Claudia M., Esquivel, Juan A., Mahalingam, Devalingam, Kelly, Kevin R., Reddy, Guru, Giles, Francis J., Nawrocki, Steffan T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2011
Предметы:
Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057822/
https://ncbi.nlm.nih.gov/pubmed/21148553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.151324
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