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Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy

Despite the promising antilymphoma activity of histone deacetylase (HDAC) inhibitors as a drug class, resistance is a significant clinical issue. Elucidating the molecular mechanisms driving HDAC inhibitor resistance and/or the specific targets that are altered in drug-resistant cells may facilitate...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Islam, Shariful, Espitia, Claudia M., Persky, Daniel O., Carew, Jennifer S., Nawrocki, Steffan T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594386/
https://ncbi.nlm.nih.gov/pubmed/33108458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002297
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