Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability

Surgical removal of colorectal cancer (CRC) liver metastases generates areas of tissue hypoxia. Hypoxia imposes a stem-like phenotype on residual tumor cells and promotes tumor recurrence. Moreover, in primary CRC, gene expression signatures reflecting hypoxia and a stem-like phenotype are highly ex...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Jongen, Jennifer M. J., van der Waals, Lizet M., Trumpi, Kari, Laoukili, Jamila, Peters, Niek A., Schenning-van Schelven, Susanne J., Govaert, Klaas M., Borel Rinkes, Inne H. M., Kranenburg, Onno
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689686/
https://ncbi.nlm.nih.gov/pubmed/29156796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21145
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