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Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
Reactive oxygen species (ROS) function as second messengers in signal transduction, but high ROS levels can also cause cell death. MTH1 dephosphorylates oxidized nucleotides, thereby preventing their incorporation into DNA and protecting tumour cells from oxidative DNA damage. Inhibitors of MTH1 (TH...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349914/ https://ncbi.nlm.nih.gov/pubmed/30692572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37316-w |
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