Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors

Rhabdoid tumors are caused by the deletion of SMARCB1, whose protein encodes the SMARCB1 subunit of the chromatin remodeling complex SWI/SNF that is involved in global chromatin organization and gene expression control. Simultaneously inhibiting the main players involved in the deregulated transcrip...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Moreno, Natalia, Holsten, Till, Mertins, Julius, Zhogbi, Annabelle, Johann, Pascal, Kool, Marcel, Meisterernst, Michael, Kerl, Kornelius
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689588/
https://ncbi.nlm.nih.gov/pubmed/29156698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18583
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