Pharmacologic inhibition of PI3K p110δ in mutant Shp2E76K-expressing mice

Juvenile myelomonocytic leukemia is a childhood malignancy that lacks effective chemotherapies and thus has poor patient outcomes. PI3K p110δ has been found to promote hyperproliferation of cells expressing mutant Shp2. In this study, we tested the efficacy of a PI3Kδ inhibitor in mice expressing th...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Oncotarget
Asıl Yazarlar: Deng, Lisa, Virts, Elizabeth L., Kapur, Reuben, Chan, Rebecca J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2017
Konular:
Priority Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689572/
https://ncbi.nlm.nih.gov/pubmed/29156682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21455
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