Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Alternative polyadenylation (APA) is a mechanism that generates multiple mRNA isoforms with different 3′UTRs and/or coding sequences from a single gene. Here, using 3′ region extraction and deep sequencing (3′READS), we have systematically mapped cleavage and polyadenylation sites (PASs) in Drosophi...

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Pubblicato in:RNA
Autori principali: Liu, Xiaochuan, Freitas, Jaime, Zheng, Dinghai, Oliveira, Marta S., Hoque, Mainul, Martins, Torcato, Henriques, Telmo, Tian, Bin, Moreira, Alexandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689002/
https://ncbi.nlm.nih.gov/pubmed/28851752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.062661.117
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