APP/Aβ Structural Diversity and Alzheimer’s Disease Pathogenesis

The amyloid cascade hypothesis of Alzheimer’s disease (AD) proposes amyloid-β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1-40 and 1-42 peptides. However, alternative APP proteolytic processing produces a complex roster of Aβ species. In a...

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Détails bibliographiques
Publié dans:Neurochem Int
Auteurs principaux: Roher, Alex E., Kokjohn, Tyler A., Clarke, Steven G., Sierks, Michael R., Maarouf, Chera L., Serrano, Geidy E., Sabbagh, Marwan S., Beach, Thomas G.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688956/
https://ncbi.nlm.nih.gov/pubmed/28811267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2017.08.007
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