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APP/Aβ Structural Diversity and Alzheimer’s Disease Pathogenesis
The amyloid cascade hypothesis of Alzheimer’s disease (AD) proposes amyloid-β (Aβ) is a chief pathological element of dementia. AD therapies have targeted monomeric and oligomeric Aβ 1-40 and 1-42 peptides. However, alternative APP proteolytic processing produces a complex roster of Aβ species. In a...
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| Publicado no: | Neurochem Int |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5688956/ https://ncbi.nlm.nih.gov/pubmed/28811267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuint.2017.08.007 |
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