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Total RNA-seq to identify pharmacological effects on specific stages of mRNA synthesis

Pharmacological perturbation is a powerful tool for understanding mRNA synthesis, but identification of the specific steps of this multi-step process that are targeted by small molecules remains challenging. Here we applied strand-specific total RNA sequencing (RNA-seq) to identify and distinguish s...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Chem Biol
Prif Awduron: Boswell, Sarah A, Snavely, Andrew, Landry, Heather M, Churchman, L Stirling, Gray, Jesse M, Springer, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688950/
https://ncbi.nlm.nih.gov/pubmed/28263964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2317
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