Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease

Due to environmental insult or innate genetic deficiency, protein folding environments of the mitochondrial matrix are prone to dysregulation, prompting the activation of a specific organellar stress-response mechanism, the mitochondrial unfolded protein response (UPR(MT)). In Caenorhabditis elegans...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Martinez, Bryan A., Petersen, Daniel A., Gaeta, Anthony L., Stanley, Samuel P., Caldwell, Guy A., Caldwell, Kim A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688521/
https://ncbi.nlm.nih.gov/pubmed/29030433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1294-17.2017
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