טוען...
Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain
Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase’s solution ensemble. However, this remains challenging d...
שמור ב:
| הוצא לאור ב: | Sci Rep |
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| Main Authors: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Nature Publishing Group UK
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5688120/ https://ncbi.nlm.nih.gov/pubmed/29142210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10697-0 |
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