Intratumoral spatial heterogeneity of BTK kinomic activity dictates distinct therapeutic response within a single glioblastoma tumor

OBJECTIVE: Despite significant recent efforts applied toward the development of efficacious therapies for glioblastoma (GBM) through exploration of GBM’s genome and transcriptome, curative therapeutic strategies remain highly elusive. As such, novel and effective therapeutics are urgently required....

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Detalhes bibliográficos
Publicado no:J Neurosurg
Main Authors: Ibrahim, Ahmed N., Yamashita, Daisuke, Anderson, Joshua C., Abdelrashid, Moaaz, Alwakeal, Amr, Estevez-Ordonez, Dagoberto, Komarova, Svetlana, Markert, James M., Goidts, Violaine, Willey, Christopher D., Nakano, Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7961807/
https://ncbi.nlm.nih.gov/pubmed/31628288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3171/2019.7.JNS191376
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