Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip

TLR4 signaling in hepatic macrophages is increased after chronic ethanol feeding. Treatment of hepatic macrophages after chronic ethanol feeding with small-specific sized hyaluronic acid 35 (HA35) normalizes TLR4 signaling; however, the mechanisms for HA35 action are not completely understood. Here...

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Pubblicato in:Sci Rep
Autori principali: Saikia, Paramananda, Roychowdhury, Sanjoy, Bellos, Damien, Pollard, Katherine A., McMullen, Megan R., McCullough, Rebecca L., McCullough, Arthur J., Gholam, Pierre, de la Motte, Carol, Nagy, Laura E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5688113/
https://ncbi.nlm.nih.gov/pubmed/29142263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15760-4
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