GSK-3β phosphorylation-dependent degradation of ZNF281 by β-TrCP2 suppresses colorectal cancer progression

Zinc finger protein 281 (ZNF281) has been recently shown to be critical for CRC progression. However, the immediate upstream regulators of ZNF281 remain unclear. Here we reported that the E3 ligase the β-transducin repeat-containing protein 2 (β-TrCP2) governs the ubiquitination and degradation of Z...

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Vydáno v:Oncotarget
Hlavní autoři: Zhu, Yuekun, Zhou, Qingxin, Zhu, Guiling, Xing, Yanwei, Li, Shiqiang, Ren, Niansheng, Liu, Tianyou, Zhu, Anlong, Bai, Yuxian, Piao, Daxun
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687630/
https://ncbi.nlm.nih.gov/pubmed/29179460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20100
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