MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation

Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20–25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination caused by CYP2D6 genetic variants were reported. Howe...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Zeng, Linjuan, Chen, Yinting, Wang, Yong, Yu, Li-Rong, Knox, Bridgett, Chen, Jiwei, Shi, Tieliu, Chen, Si, Ren, Zhen, Guo, Lei, Wu, Yuanfeng, Liu, David, Huang, Kaihong, Tong, Weida, Yu, Dianke, Ning, Baitang
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687086/
https://ncbi.nlm.nih.gov/pubmed/28552654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.05.018
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