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Conformational regulation of CRISPR-associated nucleases
Adaptive immune systems in bacteria and archaea rely on small CRISPR-derived RNAs (crRNAs) to guide specialized nucleases to foreign nucleic acids. The activation of these nucleases is controlled by a series of molecular checkpoints that ensure precise cleavage of nucleic acid targets, while minimiz...
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| Publicado en: | Curr Opin Microbiol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687066/ https://ncbi.nlm.nih.gov/pubmed/28646675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mib.2017.05.010 |
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