Conformational Dynamics of DNA Binding and Cas3 Recruitment by the CRISPR RNA-guide Cascade Complex

Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeats) RNA-guided adaptive immune systems for sequence specific elimination of foreign nucleic acids. In Escherichia coli, short CRISPR-derived RNAs (crRNAs) assemble with Cas (CRISPR-associated) proteins into a...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: van Erp, Paul B.G., Patterson, Angela, Kant, Ravi, Berry, Luke, Golden, Sarah M., Forsman, Brittney L., Carter, Joshua, Jackson, Ryan N., Bothner, Brian, Wiedenheft, Blake
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815893/
https://ncbi.nlm.nih.gov/pubmed/29035497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00649
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