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Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces are organized in an anisotropic manner to p...

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Библиографические подробности
Опубликовано в: :Mol Biol Cell
Главные авторы: De Simone, Alessandro, Gönczy, Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Cell Biology 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687019/
https://ncbi.nlm.nih.gov/pubmed/28701341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-12-0823
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