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Computer simulations reveal mechanisms that organize nuclear dynein forces to separate centrosomes

Centrosome separation along the surface of the nucleus at the onset of mitosis is critical for bipolar spindle assembly. Dynein anchored on the nuclear envelope is known to be important for centrosome separation, but it is unclear how nuclear dynein forces are organized in an anisotropic manner to p...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: De Simone, Alessandro, Gönczy, Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687019/
https://ncbi.nlm.nih.gov/pubmed/28701341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-12-0823
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