Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice

Diet soda consumption has not been associated with tangible weight loss. Aspartame (ASP) commonly substitutes sugar and one of its breakdown products is phenylalanine (PHE), a known inhibitor of intestinal alkaline phosphatase (IAP), a gut enzyme shown to prevent metabolic syndrome in mice. We hypot...

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Publicado no:Appl Physiol Nutr Metab
Main Authors: Gul, Sarah S., Hamilton, A. Rebecca L., Munoz, Alexander R., Phupitakphol, Tanit, Liu, Wei, Hyoju, Sanjiv K., Economopoulos, Konstantinos P., Morrison, Sara, Hu, Dong, Zhang, Weifeng, Gharedaghi, Mohammad Hadi, Huo, Haizhong, Hamarneh, Sulaiman R., Hodin, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686455/
https://ncbi.nlm.nih.gov/pubmed/27997218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1139/apnm-2016-0346
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