Eukaryotic-type serine/threonine kinase mediated phosphorylation at Thr(169) perturbs mycobacterial guanylate kinase activity

Guanylate kinase is an essential and conserved enzyme in nucleotide biosynthetic pathway that transfers phosphoryl group of ATP to GMP for yielding GDP. Here, we report the phosphorylation of guanylate kinase from Mycobacterium tuberculosis (mGmk) by eukaryotic-type Ser/Thr kinase, PknA. Mass spectr...

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Sparad:
Bibliografiska uppgifter
I publikationen:Biosci Rep
Huvudupphovsmän: S. Yadav, Ghanshyam, K. Ravala, Sandeep, Kachhap, Sangita, Thakur, Meghna, Roy, Abhishek, Singh, Balvinder, Karthikeyan, Subramanian, K. Chakraborti, Pradip
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2017
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5686395/
https://ncbi.nlm.nih.gov/pubmed/28963370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20171048
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