The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fluorizoline induced apoptosis in chronic lymphocyti...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Cosialls, Ana M., Pomares, Helena, Iglesias-Serret, Daniel, Saura-Esteller, José, Núñez-Vázquez, Sonia, González-Gironès, Diana M., de la Banda, Esmeralda, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, González-Barca, Eva M., Gil, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685241/
https://ncbi.nlm.nih.gov/pubmed/28619845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.162958
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