A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation

We previously described diaryl trifluorothiazoline compound 1a (hereafter referred to as fluorizoline) as a first-in-class small molecule that induces p53-independent apoptosis in a wide range of tumor cell lines. Fluorizoline directly binds to prohibitin 1 and 2 (PHBs), two proteins involved in the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Moncunill-Massaguer, Cristina, Saura-Esteller, José, Pérez-Perarnau, Alba, Palmeri, Claudia Mariela, Núñez-Vázquez, Sonia, Cosialls, Ana M., González-Gironès, Diana M., Pomares, Helena, Korwitz, Anne, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, Langer, Thomas, Iglesias-Serret, Daniel, Gil, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747186/
https://ncbi.nlm.nih.gov/pubmed/26497683
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