High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia

The bone marrow microenvironment is known to provide a survival advantage to residual acute myeloid leukemia cells, possibly contributing to disease recurrence. The mechanisms by which stroma in the microenvironment regulates leukemia survival remain largely unknown. Using reverse-phase protein arra...

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Veröffentlicht in:Haematologica
Hauptverfasser: Zeng, Zhihong, Liu, Wenbin, Tsao, Twee, Qiu, YiHua, Zhao, Yang, Samudio, Ismael, Sarbassov, Dos D., Kornblau, Steven M., Baggerly, Keith A., Kantarjian, Hagop M., Konopleva, Marina, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685227/
https://ncbi.nlm.nih.gov/pubmed/28659338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2016.162230
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