Botulinum toxins A and E inflict dynamic destabilization on t-SNARE to impair SNARE assembly and membrane fusion

Botulinum toxins (BoNT) A and E block neurotransmitter release by specifically cleaving the C- terminal ends of SNAP-25, a plasma membrane SNARE protein. Here, we find that SNAP-25A and E, the cleavage products of BoNT A and E respectively, terminate membrane fusion via completely different mechanis...

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Gepubliceerd in:Structure
Hoofdauteurs: Khounlo, Ryan, Kim, Jaewook, Yin, Linxiang, Shin, Yeon-Kyun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685167/
https://ncbi.nlm.nih.gov/pubmed/29033286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.09.004
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