Membrane Binding of α-Synuclein Stimulates Expansion of SNARE-Dependent Fusion Pore

SNARE-dependent membrane fusion is essential for neurotransmitter release at the synapse. Recently, α-synuclein has emerged as an important regulator for membrane fusion. Misfolded α-synuclein oligomers are potent fusion inhibitors. However, the function of normal α-synuclein has been elusive. Here,...

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Udgivet i:Front Cell Dev Biol
Main Authors: Khounlo, Ryan, Hawk, Brenden J. D., Khu, Tung-Mei, Yoo, Gyeongji, Lee, Nam Ki, Pierson, Josh, Shin, Yeon-Kyun
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326570/
https://ncbi.nlm.nih.gov/pubmed/34350173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.663431
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