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Botulinum toxins A and E inflict dynamic destabilization on t-SNARE to impair SNARE assembly and membrane fusion
Botulinum toxins (BoNT) A and E block neurotransmitter release by specifically cleaving the C- terminal ends of SNAP-25, a plasma membrane SNARE protein. Here, we find that SNAP-25A and E, the cleavage products of BoNT A and E respectively, terminate membrane fusion via completely different mechanis...
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| Udgivet i: | Structure |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5685167/ https://ncbi.nlm.nih.gov/pubmed/29033286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.09.004 |
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