BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability

BRCA2-deficient cells exhibit gross genomic instability, but the underlying mechanisms are not fully understood. Here we report that inactivation of BRCA2 but not RAD51 destabilizes RPA-coated single-stranded DNA (ssDNA) structures at resected DNA double-strand breaks (DSBs) and greatly enhances the...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Han, Jinhua, Ruan, Chunyan, Huen, Michael S. Y., Wang, Jiadong, Xie, Anyong, Fu, Chun, Liu, Ting, Huang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684403/
https://ncbi.nlm.nih.gov/pubmed/29133916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01759-y
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