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Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite
PURPOSE: A high interindividual variability is observed in the pharmacokinetics of clopidogrel, a widely used antiplatelet drug. In the present study, a joint parent-metabolite population pharmacokinetic model was developed to adequately describe observed concentrations of clopidogrel and its active...
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| Pubblicato in: | Eur J Clin Pharmacol |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Berlin Heidelberg
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5684285/ https://ncbi.nlm.nih.gov/pubmed/28914344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-017-2334-z |
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