Population pharmacokinetics of treosulfan and development of a limited sampling strategy in children prior to hematopoietic stem cell transplantation

PURPOSE: There is an increasing interest in use of treosulfan (TREO), a structural analogue of busulfan, as an agent in conditioning regimens prior to hematopoietic stem cell transplantation (HSCT), both in pediatric and adult populations. The aim of this study was to develop a population pharmacoki...

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Veröffentlicht in:Eur J Clin Pharmacol
Hauptverfasser: Danielak, Dorota, Twardosz, Jadwiga, Kasprzyk, Anna, Wachowiak, Jacek, Kałwak, Krzysztof, Główka, Franciszek
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2017
Schlagworte:
Pharmacokinetics and Disposition
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748442/
https://ncbi.nlm.nih.gov/pubmed/28975382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-017-2344-x
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