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Impact of CYP3A4*1G Allele on Clinical Pharmacokinetics and Pharmacodynamics of Clopidogrel
BACKGROUND AND OBJECTIVES: Resistance to the antiplatelet treatment with clopidogrel has both genetic and non-genetic causes. Polymorphic variants of cytochrome P450 3A4 isoenzyme involved in the bioactivation of clopidogrel might have an influence on responsiveness to the drug. The aim of this stud...
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| Publicado no: | Eur J Drug Metab Pharmacokinet |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer International Publishing
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5306247/ https://ncbi.nlm.nih.gov/pubmed/26891871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-016-0324-7 |
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