PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

The precise molecular mechanism underlying the regulation of early B cell lymphopoiesis is unclear. The PLCγ signaling pathway is critical for antigen receptor-mediated lymphocyte activation, but its function in cytokine signaling is unknown. Here we show that PLCγ1/PLCγ2 double deficiency in mice b...

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Publicat a:Nat Commun
Autors principals: Yu, Mei, Chen, Yuhong, Zeng, Hu, Zheng, Yongwei, Fu, Guoping, Zhu, Wen, Broeckel, Ulrich, Aggarwal, Praful, Turner, Amy, Neale, Geoffrey, Guy, Cliff, Zhu, Nan, Chi, Hongbo, Wen, Renren, Wang, Demin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684131/
https://ncbi.nlm.nih.gov/pubmed/29133930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01388-5
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