Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controvers...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Beneventano, Martina, Spampinato, Simona F., Merlo, Sara, Chisari, Mariangela, Platania, Paola, Ragusa, Marco, Purrello, Michele, Nicoletti, Ferdinando, Sortino, Maria Angela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684115/
https://ncbi.nlm.nih.gov/pubmed/29170640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00812
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