Shedding of Microvesicles from Microglia Contributes to the Effects Induced by Metabotropic Glutamate Receptor 5 Activation on Neuronal Death

Metabotropic glutamate (mGlu) receptor 5 is involved in neuroinflammation and has been shown to mediate reduced inflammation and neurotoxicity and to modify microglia polarization. On the other hand, blockade of mGlu5 receptor results in inhibition of microglia activation. To dissect this controvers...

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Bibliografiske detaljer
Udgivet i:Front Pharmacol
Main Authors: Beneventano, Martina, Spampinato, Simona F., Merlo, Sara, Chisari, Mariangela, Platania, Paola, Ragusa, Marco, Purrello, Michele, Nicoletti, Ferdinando, Sortino, Maria Angela
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5684115/
https://ncbi.nlm.nih.gov/pubmed/29170640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00812
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