Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade

MicroRNA-155 (miR-155) regulates antitumor immune responses. However, its specific functions within distinct immune cell types have not been delineated in conditional KO mouse models. In this study, we investigated the role of miR-155 specifically within T cells during the immune response to syngene...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Huffaker, Thomas B., Lee, Soh-Hyun, Tang, William W., Wallace, Jared A., Alexander, Margaret, Runtsch, Marah C., Larsen, Dane K., Thompson, Jacob, Ramstead, Andrew G., Voth, Warren P., Hu, Ruozhen, Round, June L., Williams, Matthew A., O'Connell, Ryan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Immunology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682963/
https://ncbi.nlm.nih.gov/pubmed/28912267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808121
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