Antitumor immunity is defective in T cell–specific microRNA-155–deficient mice and is rescued by immune checkpoint blockade

MicroRNA-155 (miR-155) regulates antitumor immune responses. However, its specific functions within distinct immune cell types have not been delineated in conditional KO mouse models. In this study, we investigated the role of miR-155 specifically within T cells during the immune response to syngene...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Huffaker, Thomas B., Lee, Soh-Hyun, Tang, William W., Wallace, Jared A., Alexander, Margaret, Runtsch, Marah C., Larsen, Dane K., Thompson, Jacob, Ramstead, Andrew G., Voth, Warren P., Hu, Ruozhen, Round, June L., Williams, Matthew A., O'Connell, Ryan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5682963/
https://ncbi.nlm.nih.gov/pubmed/28912267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808121
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