miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response

FLT3-ITD(+) acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD(+) AML compared with FLT3 wild-type (FLT3-WT) AML and is critical for the growth of FLT3-ITD(+) AML cells in vi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Wallace, Jared A., Kagele, Dominique A., Eiring, Anna M., Kim, Carissa N., Hu, Ruozhen, Runtsch, Marah C., Alexander, Margaret, Huffaker, Thomas B., Lee, Soh-Hyun, Patel, Ami B., Mosbruger, Timothy L., Voth, Warren P., Rao, Dinesh S., Miles, Rodney R., Round, June L., Deininger, Michael W., O’Connell, Ryan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465836/
https://ncbi.nlm.nih.gov/pubmed/28432220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-740209
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