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miR-155 promotes FLT3-ITD–induced myeloproliferative disease through inhibition of the interferon response
FLT3-ITD(+) acute myeloid leukemia (AML) accounts for ∼25% of all AML cases and is a subtype that carries a poor prognosis. microRNA-155 (miR-155) is specifically overexpressed in FLT3-ITD(+) AML compared with FLT3 wild-type (FLT3-WT) AML and is critical for the growth of FLT3-ITD(+) AML cells in vi...
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| Veröffentlicht in: | Blood |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5465836/ https://ncbi.nlm.nih.gov/pubmed/28432220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-09-740209 |
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