Structural basis of arrestin-3 activation and signaling

A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP(6)) is a non-receptor activator of arrestin-3 and report the structure of IP(6)-activated arrestin-3 at 2.4-Å resolution. IP(6)-activat...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Chen, Qiuyan, Perry, Nicole A., Vishnivetskiy, Sergey A., Berndt, Sandra, Gilbert, Nathaniel C., Zhuo, Ya, Singh, Prashant K., Tholen, Jonas, Ohi, Melanie D., Gurevich, Eugenia V., Brautigam, Chad A., Klug, Candice S., Gurevich, Vsevolod V., Iverson, T. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681653/
https://ncbi.nlm.nih.gov/pubmed/29127291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01218-8
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