Deficiency of N-Acetyltransferase Increases the Interactions of Isoniazid with Endobiotics in mouse Liver

Acetylation is the major metabolic pathway of isoniazid (INH) mediated by N-acetyltransferases (NATs). Previous reports suggest that slow acetylators have higher risks of INH hepatotoxicity than rapid acetylators, but the detailed mechanisms remain elusive. The current study used Nat1/2(−/−) mice to...

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Gepubliceerd in:Biochem Pharmacol
Hoofdauteurs: Wang, Pengcheng, Shehu, Amina I., Lu, Jie, Joshi, Rujuta H., Venkataramanan, Raman, Sugamori, Kim S., Grant, Denis M., Zhong, Xiao-bo, Ma, Xiaochao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681379/
https://ncbi.nlm.nih.gov/pubmed/28888949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.09.001
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