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Chronic treatment with isoniazid causes protoporphyrin IX accumulation in mouse liver

Isoniazid (INH) can cause hepatotoxicity. In addition, INH is contraindicated in patients suffering from porphyrias. Our metabolomic analysis revealed that chronic treatment with INH in mice causes a hepatic accumulation of protoporphyrin IX (PPIX). PPIX is an intermediate in the heme biosynthesis p...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Sachar, Madhav, Li, Feng, Liu, Ke, Wang, Pengcheng, Lu, Jie, Ma, Xiaochao
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316289/
https://ncbi.nlm.nih.gov/pubmed/27438535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00121
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