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A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver

Overdose of isoniazid (INH), an antituberculosis drug, can be life-threatening because of neurotoxicity. In clinical practice for management of INH overdose and acute toxicity, the potential of INH-induced hepatotoxicity is also considered. However, the biochemical basis of acute INH toxicity in the...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Li, Feng, Wang, Pengcheng, Liu, Ke, Tarrago, Mariana G., Lu, Jie, Chini, Eduardo N., Ma, Xiaochao
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074471/
https://ncbi.nlm.nih.gov/pubmed/27531952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.070920
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