Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

OBJECTIVE: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. METHODS: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-e...

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Vydáno v:Mol Metab
Hlavní autoři: Moir, Lee, Bochukova, Elena G., Dumbell, Rebecca, Banks, Gareth, Bains, Rasneer S., Nolan, Patrick M., Scudamore, Cheryl, Simon, Michelle, Watson, Kimberly A., Keogh, Julia, Henning, Elana, Hendricks, Audrey, O'Rahilly, Stephen, Barroso, Inês, Sullivan, Adrienne E., Bersten, David C., Whitelaw, Murray L., Kirsch, Susan, Bentley, Elizabeth, Farooqi, I. Sadaf, Cox, Roger D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681237/
https://ncbi.nlm.nih.gov/pubmed/29107289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.08.006
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