Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

OBJECTIVE: Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. METHODS: In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-e...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Moir, Lee, Bochukova, Elena G., Dumbell, Rebecca, Banks, Gareth, Bains, Rasneer S., Nolan, Patrick M., Scudamore, Cheryl, Simon, Michelle, Watson, Kimberly A., Keogh, Julia, Henning, Elana, Hendricks, Audrey, O'Rahilly, Stephen, Barroso, Inês, Sullivan, Adrienne E., Bersten, David C., Whitelaw, Murray L., Kirsch, Susan, Bentley, Elizabeth, Farooqi, I. Sadaf, Cox, Roger D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5681237/
https://ncbi.nlm.nih.gov/pubmed/29107289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.08.006
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