Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

Hepatic apoptosis is involved in the progression of alcoholic liver disease (ALD). Caspase-8, the apical initiator in death receptor-mediated apoptosis, has been implicated in acute liver injury and in non-alcoholic steatohepatitis. However, the relevance of Caspase-8 in the pathogenesis of ALD rema...

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Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Hao, Fengjie, Cubero, Francisco Javier, Ramadori, Pierluigi, Liao, Lijun, Haas, Ute, Lambertz, Daniela, Sonntag, Roland, Bangen, Jörg- Martin, Gassler, Nikolaus, Hoss, Mareike, Streetz, Konrad L, Reissing, Johanna, Zimmermann, Henning W, Trautwein, Christian, Liedtke, Christian, Nevzorova, Yulia A
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680911/
https://ncbi.nlm.nih.gov/pubmed/29072704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.532
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