Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

E-type cyclins E1 (CcnE1) and E2 (CcnE2) are regulatory subunits of cyclin-dependent kinase 2 (Cdk2) and thought to control the transition of quiescent cells into the cell cycle. Initial findings indicated that CcnE1 and CcnE2 have largely overlapping functions for cancer development in several tumo...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sonntag, Roland, Giebeler, Nives, Nevzorova, Yulia A., Bangen, Jörg-Martin, Fahrenkamp, Dirk, Lambertz, Daniela, Haas, Ute, Hu, Wei, Gassler, Nikolaus, Cubero, Francisco Javier, Müller-Newen, Gerhard, Abdallah, Ali T., Weiskirchen, Ralf, Ticconi, Fabio, Costa, Ivan G., Barbacid, Mariano, Trautwein, Christian, Liedtke, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140539/
https://ncbi.nlm.nih.gov/pubmed/30150405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807155115
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